1,3,4-oxadiazole N-oxide
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1,3,4-oxadiazole N-oxide investigation of its preparation and reactions. by Teresa Geach

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Published .
Written in English


Book details:

The Physical Object
Pagination58 leaves
Number of Pages58
ID Numbers
Open LibraryOL13752548M

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Previously unknown furoxan and 1,3,4‐oxadiazole ring ensembles incorporating two, three, and five furoxan and 1,3,4‐oxadiazole rings in different combinations were for the first time. Stereoselective synthesis of monoterpene-based 1,2,4- and 1,3,4-oxadiazole derivatives was accomplished starting from α,β-unsaturated carboxylic acids, obtained by the oxidation of (−)carenealdehyde and commercially available (−)-myrtenal. 1,2,4-Oxadiazoles were prepared in two steps via the corresponding O-acylamidoxime intermediates, which then underwent cyclisation induced by Cited by: 4. Synonym: 2-(4-Chlorophenyl)-1,3,4-oxadiazolethione, 5-(4-Chlorophenyl)-1,3,4-oxadiazole-2(3H)-thione Empirical Formula (Hill Notation): C 8 H 5 ClN 2 OS Molecular Weight:   1,2,4-Oxadiazoles show IR absorptions at – (C N), –, –, –, –, and – cm −1 〈59CR()〉.Detailed analyzes exist for the IR spectra of the parent 1,2,4-oxadiazole and some of its methyl derivatives 〈67SA(A)〉.For 3,4,5-trisubstituted 1,2,4-oxadiazolium salts strong absorptions around cm −1 were observed (in CH 2 .

The combinations of Co(II), octacyanidotungstate(V), and monodentate pyridine N-oxide (pyNO) or 4-phenylpyridine N-oxide (4-phpyNO) led to crystallization of novel crystalline phases {CoII[CoII8(pyNO)12(MeOH)12][WV(CN)8]6} (1) and {CoII[CoII8(4-phpyNO)7(MeOH)17][WV(CN)8]6}7MeOH(4-phpyNO)3 (2). In both architectures, metal–cyanide clusters are coordinated by N-oxide . Methods used for the synthesis of 3,5-substituted 1,2,4-oxadiazoles are reviewed. The syntheses are based mostly on the use of primary amidoximes and acylating agents as the initial reactants. The syntheses of a new series of derivatives of 1,2,5-oxadiazole N-oxide, benzo[1,2-c]1,2,5-oxadiazole N-oxide, and quinoxaline di-N-oxide are described. In vitro antitrypanosomal activity of these compounds was tested against epimastigote forms of Trypanosoma cruzi. For the most effective drugs, derivatives IIIe and IIIf, the 50% inhibitory dose (ID50) was determined as well as their.   The syntheses of a new series of derivatives of 1,2,5-oxadiazole N-oxide, benzo[1,2-c]1,2,5-oxadiazole N-oxide, and quinoxaline di-N-oxide are described. In vitro antitrypanosomal activity of these compounds was tested against epimastigote forms of Trypanosoma cruzi. For the most effective drugs, derivatives IIIe and IIIf, the 50% inhibitory dose (ID50) was determined as well as their.

Four new oxadiazole-bridging ligands (L1−L4) were designed and synthesized by the reaction of 2,5-bis(2-hydroxyphenyl)-1,3,4-oxadiazole with isonicotinoyl chloride and nicotinoyl chloride, respectively.L1 and L3 are unsymmetric single-armed ligands (4- or 3-pyridinecarboxylate arm), and L2 and L4 are symmetric double-armed ligands (4- or 3-pyridinecarboxylate arms). The N-oxide isomer and deoxygenated analogs were also used to confirm the participation of the oxide moiety in the fragmentation process. Online coupling of flash-vacuum pyrolysis and mass spectrometry was applied to 3,4-dicyano-1,2,5-oxadiazoleoxide (dicyanofuroxan). The reaction of oxadiazole bridging pyridyl-N-oxides (2,5-bis(4-pyridyl-N-oxide)-1,3,4-oxadiazole (A1) and 2-(4-pyridyl)(4-pyridyl-N-oxide)-1,3,4-oxadiazole (A2)) with different substituted aromatics (R-aromatics, R = –OH, –NH 2, –COOH) have been new organic co-crystals of 1–8 were synthesized and characterized by elemental analysis, FTIR spectroscopy, 1 H NMR and.   Given this background, research on the combination of 1,3,4-oxadiazole and furoxan is a subject of great research value. The authors of this paper have made sustained efforts to research new energetic compounds with high energetic performance and low sensitivity.